Table 1. Univariate and Multivariate Analyses of Clinical Variables and Proteins on Normalization of Ca-125 and Progression-Free Survival.

	Ca-125 normalization by cycle #31			Progression-free survival
Variables
	Univariate	Multivariate7		Univariate
	p-value	HR2 (95% CI)	p-value	HR6 (95% CI)	p-value
Clinical
Age3	0.57	-	-	-	-
Stage4	0.06	-	-	-	-
Residuum5	0.90	-	-	-	-
Pre-treatment Ca-1253	0.13	-	-	-	-
Proteins
JNK	0.01	6.25 (1.6-25.0)	0.01	1.61 (1.07-2.4)	0.02
EGFR	0.05	6.67 (1.3-33.3)	0.02	1.50 (0.98-2.3)	0.06
SMAD3	0.04	0.14 (0.02-0.9)	0.04	-	NS
TAZ	0.04	-	NS	1.58 (0.97-2.6)	0.07
PAI-1	0.02	-	NS	-	NS
JNKp183_185	0.05	-	NS	-	NS
YKL 40	0.04	-	NS	-	NS

Abbreviations: HR = hazard ratio; 95% CI = 95% confidence interval; NS = not significant

Notes:

¹Ca-125 normalization defined as ≤ 35 IU/ml;

²Logistic regression hazard ratio > 1 indicates lower chance of normalization of Ca-125 with higher levels of protein expression;

³variable analyzed as a continuous variable;

⁴stage 3 vs. 4;

⁵macroscopic vs. no macroscopic;

⁶Hazard ratio > 1 indicates higher risk of progression with higher levels of protein expression;

⁷Only the significant variables in univariate analysis for Ca-125 normalization were taken forward into the multivariate analysis.