Table 5.
Multiple linear regression model for the association between variants and TG levels adjusting for covariates.
| Variable | B1 | 95% confidence interval | p value |
|---|---|---|---|
| LPL-protective variant combination2 | 0.920 | 0.895 - 0.947 | <0.0001 |
| LPL-D9N3 | 1.142 | 1.000 - 1.303 | 0.048 |
| LPL-N291S3 | 1.198 | 1.048 - 1.369 | <0.01 |
| APOA5-S19W3 | 1.128 | 1.054 - 1.206 | <0.001 |
| APOA5- (-1131T/C)3 | 1.154 | 1.075 - 1.239 | <0.0001 |
| APOE-ε23 | 1.038 | 0.966 - 1.115 | 0.309 |
| APOE-ε43 | 1.109 | 1.045 - 1.176 | <0.001 |
Statistical analysis was performed excluding one subject with TG > 11.29 mmol/L and those taking lipid lowering drugs (n = 1731). R2 of the model 0.30.
1Multiplicative coefficient of the effect of each variant, obtained after undoing logarithmic transformation.
2One protective variant or two protective variants versus reference (no protective variants).
3Carriers of the minor allele (homozygous and heterozygous) versus reference (homozygous for the frequent allele)