Table 2.
Demographic, clinical characteristics and laboratory findings on admission of the 208 scrub typhus patients
| Characteristics | Severe scrub typhus (n = 89) | Non-severe scrub typhus (n = 119) |
|---|---|---|
| Demographic data | ||
| Age, mean years ± SD* | 68.56 ± 11.1 | 57.32 ± 15.7 |
| Gender, no. of male/no. of female (% of male) | 28/61(31.5) | 43/76(36.1) |
| Duration of illness before admission, days | 8.13 ± 5.4 | 6.95 ± 3.7 |
| Length of hospitalization, mean days ± SD* | 11.5 ± 9.6 | 7.21 ± 2.8 |
| Mean duration from disease onset to effective antibiotic therapy (days) | 8.34 ± 5.1 | 7.11 ± 3.7 |
| Underlying diseases (Diabetes, Liver cirrhosis, COPD) | 6(6.8%) | 4(3.3%) |
| Clinical symptoms and signs | ||
| Headache, no. (%) of patients | 74 (83.1) | 109 (91.6) |
| Myalgia, no. (%) of patients | 66 (74.2) | 95(79.8) |
| Skin rash, no. (%) of patients | 78(87.6) | 111 (93.3) |
| Eschar, no.(%) of patients* | 77 (86.5) | 117 (98.3) |
| Laboratory values | ||
| WBC count (no. of cells × 1, 000/mm3) * | 9.4 ± 4.3 | 6.6 ± 3.1 |
| Hemoglobin (g/dL) * | 12.0 ± 1.8 | 12.7 ± 1.3 |
| Platelet count (no. of cells × 1, 000/mm3) | 149.31 ± 77.3 | 153.7 ± 72.9 |
| AST (IU/L) | 100.9 ± 70.0 | 104.1 ± 86.8 |
| ALT (IU/L) | 75.0 ± 74.4 | 91.2 ± 86.5 |
| ALP (U/L) | 136.4 ± 120.0 | 118.5 ± 87.1 |
| Bilirubin (mg/dL) | 1.0 ± 1.0 | 0.8 ± 0.6 |
| Albumin (g/dL) * | 3.3 ± 0.6 | 3.8 ± 0.5 |
| LDH (U/L) | 818.5 ± 240.1 | 874.3 ± 264.2 |
| CPK (U/L) | 232.3 ± 609.5 | 263.5 ± 698.5 |
| ADA (IU/L) | 83.6 ± 24.9 | 79.6 ± 24.7 |
| Serum creatinine (mg/dL) * | 1.5 ± 0.9 | 1.0 ± 0.2 |
| Fibrinogen (mg/dL) * | 309.2 ± 97.4 | 348.2 ± 90.4 |
| CRP (mg/dL) * | 10.5 ± 5.0 | 8.1 ± 5.6 |
| ESR (mm/hr) | 19.4 ± 17.7 | 7.0 ± 15.0 |
| PT (sec) | 12.2 ± 1.0 | 12.3 ± 1.3 |
| aPTT (sec) * | 32.6 ± 5.8 | 30.5 ± 4.6 |
Values are mean ± SD.
* There was significant difference in baseline characteristics between the two groups (P < .05).
AST = aspartate aminotransferase; ALT = alanine aminotransferase; LDH = Lactate dehydrogenase; CPK = Creatine Kinase; ADA = adenosine deaminase; CRP = C-reactive protein; COPD = Chronic obstructive pulmonary disease