Table 3.
Unadjusted relative risk for each selected factor on severe scrub typhus
| Factors | Severe scrub typhus (n = 89) | Non-severe scrub typhus (n = 119) | Odds ratio (CI) | P value |
|---|---|---|---|---|
| Age(year) > 60 | 71 (79.8%) | 57 (47.9%) | 4.3 (2.3-8.1) | < 0.001 |
| Mean duration from disease onset to effective antibiotic therapy (days) | 8.34 ± 5.1 | 7.11 ± 3.7 | 0.1 | |
| Underlying diseases (Diabetes, Liver cirrhosis, COPD) | 6 (6.8%) | 4 (3.3%) | 2.1(0.6-7.8) | 0.25 |
| Headache | 74 (83.1) | 109 (91.6) | 0.5 (0.2-1.1) | 0.07 |
| Myalgia | 66 (74.2) | 95(79.8) | 0.7(0.4-1.4) | 0.3 |
| Skin rash | 78(87.6) | 111 (93.3) | 0.5 (0.2-1.3) | 0.2 |
| Eschar | 77 (86.5) | 117 (98.3) | 0.1 (0.02-0.5) | 0.004 |
| WBC count (> 10, 000/mm3) | 37 (41.6%) | 16 (13.4%) | 4.6 (2.3-9.0) | < 0.001 |
| Hemoglobin (≤ 10 g/dL) | 10 (11.2%) | 2 (1.7%) | 0.14(0.03-0.63) | 0.01 |
| Platelet count (≤ 100, 000/mm3) | 28(31.5%) | 25(21.0%) | 0.58(0.31-1.09) | 0.09 |
| AST (>40 IU) | 79(88.8%) | 108 (90.8%) | 1.24(0.50-3.07) | 0.64 |
| ALT (>40 IU) | 84(94.4%) | 106 (89.1%) | 1.0 (1.0-1.0) | 0.16 |
| ALP (>200 U/L) | 19(21.6%) | 17 (14.9%) | 1.6(0.79-3.3) | 0.19 |
| Bilirubin (>1.0 mg/dL) | 23(25.8%) | 22 (18.5%) | 1.54(0.79-2.98) | 0.2 |
| Albumin (≤ 3.0 g/dL) | 28(31.5%) | 6(5.1%) | 8.5(3.32-21.64) | > 0.001 |
| LDH (>800 U/L) | 37(43.0%) | 63(53.8%) | 0.65(0.37-1.13) | 0.13 |
| CPK (>200 U/L) | 24(27.9%) | 31(26.7%) | 1.06(0.57-1.98) | 0.85 |
| ADA (<100 IU/L) | 13(22.0%) | 13(19.4%) | 1.17(0.50-2.78) | 0.72 |
| Serum creatinine (> 1.4 mg/dL) | 31(34.8%) | 3(2.5%) | 20.7(6.06-70.4) | < 0.001 |
| Fibrinogen (≤ 150 mg/dL) | 6(7.2%) | 3(2.8%) | 0.37(0.09-1.51) | 0.17 |
| CRP (> 10 mg/dL) | 37(44.6%) | 29(24.8%) | 2.44(1.34-4.46) | 0.004 |
| ESR (> 20 mm/hr) | 33(39.8%) | 41(35.3%) | 1.21(0.68-2.16) | 0.53 |
| PT (> 15 sec) | 2(2.2%) | 2(1.7%) | 1.31(0.18-9.49) | 0.79 |
| aPTT (>40 sec) | 9(10.1%) | 4 (3.4%) | 3.15(0.94-10.59) | 0.06 |
Abbreviations as in Table 1