Table 1.

Performance of single folding indexes on set A

	Sn	Sp	fp	AUC
HQ	0.77	0.90	0.10	0.86
<P>	0.82	0.87	0.13	0.90
<Ec>	0.90	0.93	0.07	0.96
gVSL2	0.92	0.85	0.15	0.95
Poodle-W	0.74	0.93	0.07	0.94

Performance of HQ, mean packing <P>, mean pairwise energy <E_c>, gVSL2 and Poodle-W in discriminating natively unfolded proteins from folded ones in the set A (Prilusky et al. [26]). Sensitivity (S_n), specificity (S_p,), rate of false positives (f_p) and the area under curve (AUC) are defined in Methods. Mean packing threshold is fixed at 20.55 and mean pairwise energy threshold is fixed at -0.37 a.e.u.