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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Apr 23;29(7):1039–1045. doi: 10.1161/ATVBAHA.109.185405

Figure 1. Platelet response to injury in vivo.

Figure 1

Figure 1

Platelet accumulation (green) in cremaster muscle arterioles damaged with a pulsed laser. (A&B) Video captures 2 min after injury. The WT and sema4D(-/-) mice were on a normal diet. LDLR(-/-) and sema4D(-/-)LDLR(-/-) mice were studied after 6 months on a high fat diet. (C&D) Median fluorescence intensity. WT: 29 injuries in 4 mice. Sema4D(-/-): 23 injuries in 3 mice. LDLR(-/-): 26 injuries in 3 mice. Sema4D(-/-)LDLR(-/-): 25 injuries in 3 mice. (E) Mean thrombus area. (F) Frequency of complete occlusion.