Table 1. Quantification of stress-induced mutation rates from multiple experiments.
| Relevant genotypes compareda | Experimentb identification # | Mean difference in mutation rate from control ± S.E.M.c | P-valued | |
| Mutant | Isogenic control | |||
| polA12(TS) | Pol+ | 1–4 | 2.8±0.3 | 0.030 |
| polA1 | Pol+ | 17–19 | 5.9±0.9 | 0.050 |
| polA6 | Pol+ | 17–19 | 7.3±2.1 | 0.050 |
| polBΔ1 | Pol+ | 5–10 | 5.6±0.5 | 0.004 |
| polA1 polBΔ1 | polA1 | 20–22 | 3.7±1.3 | 0.050 |
| polA1 polBΔ1 | polBΔ1 | 20–22 | 5.7±1.5 | 0.050 |
| polA1 polBΔ1dinB10 | polA1 polBΔ1 | 20–22 | 0.016±0.005 | 0.050 |
| polBΔ1dinB10 | dinB10 | 22–24 | 0.74±0.18 | 0.663 |
| dinB10 | Pol+ | 20–22 | 0.23±0.06 | 0.050 |
| dnaE915 | Pol+ | 11–13 | 0.20±0.02 | 0.050 |
| dnaQ | DnaQ+ | 14–16 | 0.92±0.4 | 0.663 |
| umuDC | Pol+ | 23–25 | 1.2±0.17 | 0.513 |
| umuDC dinB10 | dinB10 | 23–25 | 1.1±0.24 | 0.663 |
| lexA(Ind−) | Lex+ | 1–4 | 0.29±0.09 | 0.043 |
| lexA(Def) | Lex+ | 5–13 | 1.2±0.2 | 0.508 |
| polA12(TS) lexA(Ind−) | lexA(Ind−) | 1–4 | 3.1±0.6 | 0.060 |
| polBΔ1 lexA(Def) | lexA(Def) | 5–10 | 6.3±1.1 | 0.004 |
| dnaE915 lexA(Def) | lexA(Def) | 11–13 | 0.28±0.1 | 0.050 |
| Other comparisons | ||||
| polA1 polBΔ1 | Pol+ | 20–22 | 16±5 | 0.050 |
| polA1 polBΔ1 dinB10 | dinB10 | 20–22 | 0.99±0.05 | 1.000 |
| polA1 | polA6 | 17–19 | 1.2±0.2 | 0.513 |
aSee Table 2 for full strain genotypes and information. “lexA(Def)” strains also carry sulA and psiB mutations [49].
bEach experiment is one such as those shown in Figure 1A–I. Experiments are identified according to strains tested in parallel. Raw data for this table are given in Table S1.
cMutation rates (mutants per day) are calculated as the number of new Lac+ colonies arising between days 4 and 5 (per [30]). The values listed represent the fold difference between two strains, averaged from multiple experiments in which the strains were tested in parallel, as in [49].
dP-values were obtained using the non-parametric Mann-Whitney Rank Sum test (SYSTAT 11 statistics software by SYSTAT Software Inc.) on rates from multiple experiments of strains tested in parallel, as in [49].