Table 6. Survival of BALB/c mice after intranasal challenge with S. pneumoniae ATCC6303 or A66.1 strains, after subcutaneous immunization.
ATCC6303 (serotype 3, PspA5) | A66.1 (serotype 3, PspA2) | |||||
alive/total | % of survival | P * | alive/total | % of survival | P * | |
Non | 0/6 | --- | --- | 0/5 | --- | --- |
DT | 0/6 | --- | --- | 0/6 | --- | --- |
DTPlow | 0/6 | --- | --- | 0/6 | --- | --- |
PspA5 | 2/6 | 33.3 | 0.22 | 0/6 | --- | --- |
PspA5 + DT | 4/6 | 66.6 | 0.03 | 3/6 | 50 | 0.09 |
PspA5 + DTPlow | 6/6 | 100 | 0.001 | 4/6 | 66.6 | 0.03 |
Fisher exact test.