Skip to main content
. 2010 May 27;6(5):e1000966. doi: 10.1371/journal.pgen.1000966

Figure 8. A working model for limiting DNA degradation at telomeres.

Figure 8

In G1, Yku protects telomeres from Exo1, while Rap1, Rif1 and Rif2 mainly act by preventing MRX access. As MRX action is still inhibited by Rap1, Rif1 and Rif2 in yku70Δ G1 cells, Yku might protect G1 telomeres also from MRX. In G2, only Rap1 and Rif2 still exert their inhibitory effects on telomere processing. Telomere resection can take place in G2 because Yku does not exert its inhibitory effect and Cdk1 activity potentiates nuclease actions.