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. 2010 May 27;6(5):e1000921. doi: 10.1371/journal.ppat.1000921

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Mice (n = 10 per group) were treated with CLDC+MPF i.v. 3 days prior to intranasal challenge with SchuS4. Significantly more CLDC+MPF treated mice survived infection compared to untreated controls (p = 0.0027). (B) Wild type (WT) or nos2/gp91^−/−mice (n = 5 per group) were treated with CLDC+MPF 3 days prior to challenge with SchuS4. Sixty percent of CDLC+MPF treated WT mice survived infection, whereas significantly fewer nos2/gp91^−/− survived (p = 0.0385). Data are representative of two experiments.