Figure 2. IS-blended B. mallei genomes.

Locations of ISBma1, ISBma2, and IS407A and large deletions in each B. mallei strain were mapped back to the reference genome of B. pseudomallei K96243 to show their relative positions. For simplicity, these features are not displayed to scale, but are shown in boxes of equal sizes (for a scaled view of the same data, see Fig. S1). The IS elements were numbered in the order in which they appear in the reference chromosomes. The 2^nd element in chromosome 1 is denoted by an *, and is the IS407A insertion that disrupted fliP, which encodes a key factor for flagella formation. The numbers in red indicate the IS elements that were disrupted by a neighboring IS407A element. Each BRU is denoted as an open box and by sequential numbers, which are preceded by A or B for chromosome 1 or chromosome 2, respectively. For additional information, see Figure S1 and Tables S1 and S2, in which the IS elements are listed with their names, composed of the sequential numbers, the IS species to which they belong (i.e. ISBma1, ISBma2, and IS407A), and their distribution patterns among the B. mallei strains (i.e., _A: present in all the strains; _B: present in only some strains; and _C: present in a single strain).