Fig. 2.

Respiratory foregut length analysis. Box plots showing total respiratory foregut length (A) and corresponding lengths of divided and undivided segments (B) according to gestational age. (A) Unaffected (normal phenotype) and affected (abnormal phenotype) Adriamycin-treated embryos are indistinguishable morphologically at E10.5, and their lengths are grouped together (red box). Note the closely similar overall foregut growth trajectories in all groups. (B) Lengths of undivided (yellow boxes) and divided (green boxes) foregut are shown for saline-treated controls (upper graph) and affected Adriamycin-treated embryos (lower graph). Unaffected Adriamycin-treated embryos have been omitted for clarity. Note the progressive division of the foregut in controls, but persistence of undivided foregut in affected Adriamycin-treated embryos.