Fig. 5.

Comparison between the breadth of the antibody response to Msp2 and bacteremia following challenge in vaccinees. Bacteremia, as represented by the percent of infected erythrocytes, was determined by daily counting of A. marginale inclusion bodies in Giemsa stained blood smears. The antibody response specifically targeting the CR and HVR of Msp2 was determined using peptides representing each region of Msp2 in ELISAs. The breadth score represents the mean number of peptides recognized by each animal at a ≥1:10 serum dilution. Spearman rank order correlation coefficient is reported.