Table 3.
The number of peptides and mean titers of the total IgG anti-Msp2 specific antibody response after immunization and after challenge.
| Immunogen | Animal ID | Immunizeda |
Bacteremia | |||
|---|---|---|---|---|---|---|
| CR |
HVR |
|||||
| # peptides recognizedb | Mean (Max) titerc | # peptides recognized | Mean (Max) titer | Max. % infected RBCs | ||
| Complexes | 5933 | 6 | 145 (640) | 14 | 374 (1280) | 4.5% |
| Complexes | 5961 | 2 | 60 (640) | 7 | 277 (1280) | 3.4% |
| Complexes | 5972 | 1 | 10 (10) | 12 | 32 (80) | 2.7% |
| Complexes | 5946 | 4 | 210 (640) | 13 | 222 (640) | Protectedd |
| Complexes | 5952 | 5 | 232 (640) | 12 | 225 (640) | Protected |
| Mean | 2.8 | 131 | 11.6 | 226 | ||
| Outer membranes | 5953 | 3 | 440 (640) | 16 | 338 (1280) | 6.4% |
| Outer membranes | 5966 | 2 | 45 (80) | 12 | 43 (160) | 2.4% |
| Outer membranes | 5978 | 3 | 30 (40) | 14 | 40 (40) | 1.7% |
| Outer membranes | 5982 | 1 | 320 (320) | 12 | 205 (320) | Protected |
| Outer membranes | 5975 | 1 | 20 (20) | 8 | 330 (640) | Protected |
| Mean | 2.0 | 171 | 12.4 | 191 | ||
| Infectede | ||||||
| Adjuvant | 5969 | 2 | 30 (40) | 16 | 365 (1280) | 31.0% |
| Adjuvant | 5967 | 3 | 30 (40) | 12 | 1030 (5120) | 19.0% |
| Adjuvant | 5958 | 1 | 80 (80) | 10 | 412 (1280) | 10.8% |
| Adjuvant | 5979 | 3 | 120 (320) | 15 | 251 (1280) | 10.3% |
| Adjuvant | 5974 | 2 | 165 (320) | 11 | 470 (1280) | 5.3% |
| Mean | 2.2 | 85 | 12.8 | 506 | ||
a
Specific antibody response measured after the final immunization and prior to challenge.
b
The number of peptides recognized from either the CR or HVR at a 1:10 serum dilution.
c
The mean of the titers for all peptides recognized by each serum sample. The maximum titer for each serum sample is reported in parentheses.
d
Protected from infection as defined by negative PCR and repeated negative blood smears.
e
Specific antibody response measured 45 days after infection with A. marginale.