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. 2010 May;52(5):705–711. doi: 10.1016/j.jhep.2009.10.037

Fig. 2.

Fig. 2

Effect of CDCA on transcription of steroid-metabolising enzymes. (A) Abundance of mRNAs of rat 5β-reductase and Cyp7a1 but not 3αHSD was suppressed in H4iiE cells by CDCA (100 μM), n = 5. (B) Activity of the promoter of human 5β-reductase was reduced by CDCA (50 μM). Data are fold induction of luciferase activity relative to control plasmid. (n = 3 triplicates), mean ± SEM; p <0.05, ∗∗∗p <0.001 vs. vehicle.