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. 2010 May 27;340:c2451. doi: 10.1136/bmj.c2451

Table 3.

 Cox regression models for toothbrushing and death from cardiovascular disease (CVD)

Toothbrushing Fatal CVD events/total Hazard ratio (95% CI)
Adjusted for age/sex Model 1* Model 2†
Total 170/11 869
Twice a day 97/8481 1.0 (reference) 1.0 (reference) 1.0 (reference)
Once a day 54/2850 1.2 (0.8 to 1.8) 1.1 (0.8 to 1.5) 1.1 (0.8 to 1.5)
<Once a day 19/538 2.4 (1.5 to 4.0) 1.6 (1.0 to 2.8) 1.5 (0.9 to 2.6)
P value for trend 0.003 0.194 0.345

*Adjusted for age, sex, socioeconomic group, smoking, physical activity, and visits to dentist.

†Additionally adjusted for BMI, family history of cardiovascular disease, hypertension (diagnosed by doctor or clinic blood pressure >140/90 mm Hg), diabetes diagnosed by doctor.