Figure 3.

Bortezomib reversibly impairs systolic, but not diastolic, heart muscle function in rats. Wistar rats were treated for 3 weeks with 0.2 mg/kg i.p. bortezomib (thrice weekly) followed by 3-week wash-out. Control animals received diluent. At indicated time points, echocardiographic examination was performed. Graphs present selected echocardiographic parameters in bortezomib-treated rats (scattered line) and control animals (solid line). Data are mean ± SD. *P < 0.001 vs controls (two-tailed Student’s t-test). A: LV ejection fraction. B: LV fractional shortening. C: LV systolic area. D: LV diastolic area.