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Staining of Wnt1 during 2AAF/PHx. A: Day 0. B: Day 3. C: Day nine. D: Day 13. Wnt1 is produced by hepatocytes within hours of PHx, as seen in liver obtained at the time of PHx. Pericentral hepatocytes production of Wnt1 can be seen as early as Day three, and levels increase throughout oval cell induction. Hepatocytes engulfed by the migrating oval cells express high levels of Wnt 1 (black arrow). Magnification, ×20.
