Skip to main content
. 2010 Jun;176(6):2732–2742. doi: 10.2353/ajpath.2010.080486

Figure 5.

Figure 5

H&E of livers from shRNA-treated animals. 2AAF/PHx: A, D, and G; SCR shRNA–treated: B, E, and H; Wnt1 shRNA–treated: C, F, and I. Day 9: A–C; Day 13: D–F; Day 21: G–I. Histologically livers in Wnt shRNA–treated animals are similar to nontreated or SCR-treated individuals at Day nine. However, as early as 13 to 15 days after PHx ADH appears in Wnt shRNA–treated animals (arrow). Ultimately, 21 days after PHx, Wnt shRNA–treated animals exhibited large regions of ADH (outline) as early as Day 15 and persistent oval cell streaming from portal triads to other portal triads (arrow). SCR shRNA–treated animals were unremarkable. Magnification, ×40.