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Altered CaMKII expression was correlated with synaptophysin loss in the hippocampus. We measured synaptophysin expression by quantitative immunoblotting to evaluate synaptic density in the hippocampus of SIV-infected macaques. CaMKII expression was strongly correlated with hippocampal synaptophysin levels (r = 0.64, P = 0.046, Pearson correlation coefficient). SIVE− animals represented by triangle symbols pointing up; SIVE+ animals represented by triangles pointing down.
