Figure 8.
Intracellular pathways of LPA production and degradation. LPA can be produced from either PA or monoacylglycerol (MAG) by PLA2 and MAG-kinase, respectively, whereas it is degraded by LPAATα and lipid phosphate phosphatase (LPP)1. The link between the FABPs and transport of LPA to the cytoplasm has not been proven yet. DAG (K) indicates diacylglycerol (kinase); ER, endoplasmic reticulum; MGAT, monoacylglycerophosphate acyltransferase; GPAT, glycerophosphate acyltransferase; G3P, glycero-3-phosphate.