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. 2010 May 10;120(6):2218–2229. doi: 10.1172/JCI40141

Figure 5. Therapeutic treatment with M1′-specific antibody specifically reduces IgE in a mouse model of allergic asthma.

Figure 5

(A) Experimental design for therapeutic M1′-specific antibody treatment of mouse allergic asthma model. Human M1′ knockin mice (n = 8 per group) were immunized with TNP-OVA/alum on day 0 and challenged with 7 daily aerosol administrations of TNP-OVA, starting on day 35. Mice were treated with 100 μg of M1′-specific antibody 47H4 or control mIgG1 antibody daily from day 39 through day 45. Treatment with M1′-specific antibody 47H4 antibody reduced (B) TNP-OVA–specific IgE levels, but did not affect (C) TNP-OVA–specific IgG1 levels. Treatment with M1′-specific antibody 47H4 antibody also reduced (D) the number of IgE-producing cells, but did not affect (E) the percentage of total syndecan+ plasma cells in the spleen, as measured on day 63. Results are mean ± SD. *P < 0.05 (Bonferroni correction for pairwise comparisons); **P < 0.05 (Dunnett’s test).