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. 2010 May 17;120(6):1824–1835. doi: 10.1172/JCI41414

Figure 6. Inflammation-associated field effects in p120 KO tissue.

Figure 6

(A) p120 KO and control 16-day-old mice were injected with BrdU, either 2 hours (proliferation) or 30 hours (migration) prior to sacrifice. Sections of the small intestine were costained with antibodies to BrdU (orange) and pp120 (green). (B) Sections of small intestine from WT and p120 KO mice were stained with antibodies to Ezrin or pERM. (C) Sections of small intestine from WT and p120 KO mice were stained with an antibody to phospho-Jun (pJun). Unlike changes in E-cadherin abundance, most other alterations were not restricted to mosaic patches of p120 ablation (e.g., arrows in A), and thus were not cell autonomous. Instead, most phenotypes were global (e.g., arrowheads in C), reflecting the type of widespread field effect frequently associated with inflammation. Original magnification, ×20.