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. 2010 May 17;120(6):1914–1924. doi: 10.1172/JCI42164

Figure 5. Heterologous overexpression of GRP78 in CHO cells makes them more susceptible to R. oryzae–induced invasion and subsequent damage.

Figure 5

The C.1 cell line, which was derived from parental DHFR-deficient CHO cells engineered to overexpress GRP78, was found to overexpress GRP78 (A). *P = 0.01 compared with parent cells by nonparametric Wilcoxon rank-sum test; n = 6 per each group. C.1 cells were able to endocytose more R. oryzae germlings (data derived from >950 fungal cells interacting with approximately 300 CHO cells/each group/experiment, with an average of 40.9% being endocytosed in the parent cells) (B) and were more susceptible to R. oryzae–induced damage (C). *P < 0.005 compared with parent cells by Wilcoxon rank-sum test. n = 6 slides per group from 3 independent experiments for endocytosis, and n = 6 wells per group from 2 independent experiments for damage assay. Data are expressed as median ± interquartile range.