Table III. Less abundant proteins in AMD Bruch membrane/choroid.
Adjusted mean protein ratios (AMD/control), S.E., p values, and subcellular source for less abundant proteins from all 24 AMD donor tissues analyzed (from supplemental Table 36) are shown. Less abundant proteins exhibited mean ratios at least 1 S.D. below the median and p values <0.06 (see Fig. 2). All proteins were quantified in ≥3 AMD donor tissues (median ratio = 1.01, S.D. = 0.15, n = 556). Majority fraction proteins were quantified in ≥16 AMD tissues (median ratio = 0.98, S.D. = 0.09, n = 113 proteins). Protein subcellular source is from the Swiss Protein Database: A, secreted; B, cytoplasmic; C, membrane; D, nuclear.
| Swiss-Prot accession number | Subcellular source | Protein | AMD donor frequency (total = 24) | Mean protein ratio | S.E. | p value |
|---|---|---|---|---|---|---|
| Regulatory processes | ||||||
| P21926 | C | CD9 antigen | 21 | 0.88 | 0.06 | 0.055 |
| P22748 | B | Carbonic anhydrase 4 | 20 | 0.84 | 0.06 | 0.056 |
| P62158 | B | Calmodulin | 14 | 0.84 | 0.05 | 0.001 |
| Q8IZP2 | B | Protein FAM10A4 | 3 | 0.83 | 0.04 | 0.035 |
| P02749 | A | β2-Glycoprotein 1 | 15 | 0.82 | 0.05 | 0.001 |
| Q03135 | C | Caveolin-1 | 22 | 0.78a | 0.04 | 0.036 |
| Q14112 | A | Nidogen-2 | 12 | 0.71 | 0.10 | 0.005 |
| Q9BXN1 | A | Asporin | 10 | 0.70a | 0.10 | 0.005 |
| Immune response and defense processes | ||||||
| P04439 | C | HLA class I histocompatibility antigen, A-3α | 5 | 0.82 | 0.07 | 0.047 |
| P02743 | A | Serum amyloid P component | 24 | 0.82 | 0.04 | 0.042 |
| P15157 | A | Tryptase α1 | 4 | 0.54a | 0.12 | 0.016 |
| Other processes | ||||||
| Q9BX97 | C | Plasmalemma vesicle-associated protein | 3 | 0.72 | 0.07 | 0.040 |
| P00403 | C | Cytochrome c oxidase subunit 2 | 4 | 0.70a | 0.09 | 0.026 |
a Ratios at least 2 S.D. below the median.