Table III. Potential angiogenic and antiangiogenic cytokines differentially regulated under Hx and Reox conditions.
48N, 48-h normoxia; 48H, 48-h hypoxia; 72H, 72-h hypoxia; 48H-24R, 48-h hypoxia followed by 24-h normoxia. Selected cytokine list was subjected to one-way analysis of variance and showed statistical difference by a p value of less than 0.05. Intensity and S.D. of selected cytokines is supplied in supplemental Table S2.
| No. | Protein | -Fold induction |
|||
|---|---|---|---|---|---|
| 48N | 48H | 72H | 48H-24R | ||
| Increased cytokines under hypoxia | |||||
| 1 | IL-3 | 1.0 | 8.5 | 3.0 | 8.1 |
| 2 | MMP-13 | 1.0 | 4.5 | 5.9 | 3.1 |
| 3 | Angiogenin | 1.0 | 3.4 | 3.5 | 0.6 |
| 4 | IL-1α | 1.0 | 2.0 | 4.3 | 1.7 |
| 5 | GRO | 1.0 | 1.8 | 5.2 | 1.5 |
| GRO-α | 1.0 | 2.1 | 2.6 | 2.2 | |
| 6 | PDGF-BB | 1.0 | 1.0 | 5.4 | 2.0 |
| 7 | VEGF | 1.0 | 1.2 | 1.5 | 1.7 |
| 8 | G-CSF | 1.0 | 2.0 | 2.3 | 1.7 |
| 9 | GM-CSF | 1.0 | 0.5 | 1.8 | 0.6 |
| Decreased cytokines under hypoxia | |||||
| 1 | IGF-II | 1.0 | 0.5 | 0.8 | 0.9 |
| 2 | TIMP-4 | 1.0 | 0.4 | 0.4 | 0.8 |
| 3 | TIMP-2 | 1.0 | 0.4 | 0.5 | 0.8 |