FIGURE 6.

Ability of mitochondria to release LOOH: comparison between wild-type and UCP3-null mitochondria and effects of rotenone and GDP on this process. Results are means ± S.E. of six (wild-type) and four (UCP3-null) independent experiments, each one performed in duplicate. For a given mitochondrial type, error bars labeled with different letters are significantly different (p < 0.01). Black bars, mitochondria with AA; white bars, mitochondria with AA plus GDP; gray bars, mitochondria with AA plus rotenone; hatched bars, mitochondria with AA plus rotenone and GDP. *, significant difference versus the same experimental condition in wild-type mitochondria (p < 0.01). prot, protein.