TABLE 2.
Functional properties of EDL muscles from mature mice
Data are mean ± S.D. for n = 4–5 male and female mice, age 25 weeks. *, p < 0.05 versus C57; †, p < 0.05 vs. gsg−/− by one-way ANOVA followed by Tukey post hoc comparisons. CSA, cross-sectional area; N, newtons.
| Strain | Treatment | Mass | CSA | Tetanic force | Specific force |
|---|---|---|---|---|---|
| mg | mm2 | mN | N/cm2 | ||
| C57 | None | 9.1 ± 0.3 | 1.64 ± 0.11 | 349 ± 16 | 21.4 ± 1.5 |
| gsg−/− | None | 12.2 ± 1.6* | 2.00 ± 0.32 | 316 ± 71 | 15.9 ± 2.7* |
| gsg−/− | AAVWTgsg | 10.0 ± 1.8 | 1.68 ± 0.24 | 357 ± 62 | 21.3 ± 1.7† |
| gsg−/− | AAVY6Agsg | 11.4 ± 1.7 | 1.96 ± 0.22 | 342 ± 80 | 17.3 ± 2.9 |