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Comparison of interactions of guanosine nucleotide exchange factors IpgB2 (A–C), Map (D–F (24)), and the DH/PH domain of PDZ-RhoGEF (G–I (52)) (in blue color) with the GTPases RhoA and Cdc42 (in brown color) as indicated. The interactions are shown for three characteristic regions of the GTPase (switch I and II and the β123 region). Water molecules are red spheres; Mg2+ is shown in yellow.
