Table 3.

Associations between Gleason score and 8q24/17q variants, comparing men with Gleason score 8–10 to Gleason score 2–6

SNP	PHS OR (95% CI)†	Gelb Center OR (95% CI)†	FHCRC OR (95% CI)†	Combined OR (95% CI)
rs13254738
AA	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
AC	1.10 (0.77,1.57)	0.90 (0.74,1.09)	0.85 (0.56,1.29)	0.93 (0.79,1.09)
CC	1.09 (0.64,1.87)	0.90 (0.66,1.23)	1.35 (0.75,2.40)	1.01 (0.79,1.29)
rs6983561
AA	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
AC/CC	1.10 (0.62,1.95)	1.01 (0.72,1.41)	0.98 (0.53,1.83)	1.02 (0.79,1.33)
rs6983267
TT	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
GT	0.84 (0.54,1.30)	0.80 (0.63,1.00)	0.86 (0.52,1.42)	0.82 (0.67,0.99)*
GG	1.15 (0.72,1.82)	0.68 (0.53,0.87)*	0.93 (0.54,1.61)	0.85 (0.61,1.20)
rs7000448
CC	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
CT	0.97 (0.68,1.39)	0.88 (0.72,1.08)	1.00 (0.66,1.52)	0.91 (0.78,1.07)
TT	0.84 (0.49,1.41)	0.89 (0.68,1.17)	0.82 (0.42,1.58)	0.87 (0.70,1.09)
rs1447295
CC	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
CA/AA	0.88 (0.59,1.31)	1.10 (0.89,1.36)	0.88 (0.56,1,39)	1.02 (0.86,1.22)
rs7008482
TT	1.00 (ref)	1.00 (ref)	-	1.00 (ref)
GT	0.82 (0.58,1.17)	0.87 (0.72,1.06)	-	0.86 (0.73,1.02)
GG	1.08 (0.63,1.85)	0.76 (0.56,1.03)	-	0.84 (0.62,1.15)
rs4430796
GG	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
AG	1.08 (0.69,1.69)	0.97 (0.77,1.23)	1.03 (0.62,1.71)	1.00 (0.82,1.21)
AA	1.04 (0.63,1.71)	0.96 (0.74,1.25)	0.92 (0.53,1.59)	0.97 (0.78,1.20)
rs1859962
TT	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
GT	1.28 (0.84,1.93)	1.05 (0.84,1.32)	0.88 (0.55,1.42)	1.06 (0.88,1.28)
GG	0.98 (0.61,1.59)	1.00 (0.77,1.30)	0.82 (0.48,1.42)	0.97 (0.78,1.20)

^†All results from unconditional logistic regression, adjusted for age at diagnosis

^*p<0.05