Table 4.

Associations between stage and 8q24/17q variants, comparing men with pathologic stage T3/T4 to T2

SNP	PHS OR (95% CI)†	Gelb Center OR (95% CI)†	FHCRC OR (95% CI)†	Combined OR (95% CI)
rs13254738	p*=0.61	p=0.78	p=0.43	p=0.68
AA	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
AC	1.23 (0.77,1.97)	1.15 (0.91,1.47)	1.11 (0.79,1.57)	1.15 (0.96,1.38)
CC	0.63 (0.29,1.38)	0.94 (0.64,1.37)	1.19 (0.72,1.97)	0.96 (0.73,1.28)
rs6983561	p=0.44	p=0.24	p=0.23	p=0.20
AA	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
AC/CC	0.73 (0.33,1.63)	1.28 (0.85,1.93)	1.36 (0.83,2.25)	1.21 (0.90,1.63)
rs6983267	p=0.94	p=0.007	p=0.89	p=0.27
TT	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
GT	0.56 (0.31,0.99)†	0.73 (0.55,0.97)‡	0.92 (0.59,1.43)	0.74 (0.60,0.93)
GG	0.91 (0.50,1.68)	0.65 (0.47,0.88)‡	1.01 (0.62,1.63)	0.79 (0.59,1.05)
rs7000448	p=0.38	p=0.14	p=0.70	p=0.09
CC	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
CT	0.64 (0.39,1.03)	0.87 (0.68,1.12)	1.03 (0.73,1.45)	0.87 (0.70,1.08)
TT	0.91 (0.48,1.73)	0.78 (0.55,1.11)	0.86 (0.51,1.45)	0.82 (0.63,1.07)
rs1447295	p=0.49	p=0.75	p=0.37	p=0.67
CC	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
CA/AA	1.21 (0.71,2.05)	0.96 (0.73,1.25)	0.84 (0.57,1.23)	0.96 (0.78,1.17)
rs7008482	p=0.83	p=0.02		p=0.03
TT	1.00 (ref)	1.00 (ref)	-	1.00 (ref)
GT	1.12 (0.70,1.78)	0.89 (0.70,1.13)	-	0.93 (0.76,1.15)
GG	0.76 (0.33,1.75)	0.57 (0.37,0.87)‡	-	0.61 (0.41,0.89)‡
rs4430796	p=0.63	p=0.77	p=0.95	p=0.97
GG	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
AG	1.06 (0.56,1.97)	0.84 (0.62,1.13)	0.82 (0.54,1.25)	0.86 (0.69,1.07)
AA	0.89 (0.45,1.74)	1.01 (0.73,1.39)	0.95 (0.60,1.49)	0.98 (0.76,1.25)
rs1859962	p=0.21	p=0.07	p=0.36	p=0.54
TT	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
GT	0.99 (0.57,1.72)	1.36 (1.01,1.83)‡	1.32 (0.87,1.99)	1.28 (1.03,1.60)‡
GG	0.68 (0.36,1.28)	1.39 (1.00,1.92)	1.26 (0.80,2.00)	1.14 (0.79,1.65)

^†All results from unconditional logistic regression, adjusted for age at diagnosis

^*All p-values for 1 d.f. test

^‡p<0.05