Table 5.
Mean values of age at diagnosis by 8q24/17q genotypes and cumulative number of risk alleles
| SNP | PHS Mean (s.e.)† |
Gelb Center Mean (s.e.)† |
FHCRC Mean (s.e.)† |
|---|---|---|---|
| rs13254738 | p=0.94 | p=0.0004 | p=0.26 |
| AA | 70.6 (0.3) | 61.4 (0.2) | 59.7 (0.3) |
| AC | 70.4 (0.3) | 62.4 (0.2) | 60.3 (0.3) |
| CC | 70.5 (0.6) | 62.8 (0.4) | 59.6 (0.6) |
| rs6983561 | p=0.43 | p=0.25 | p=0.80 |
| AA | 70.5 (0.2) | 62.0 (0.1) | 60.0 (0.2) |
| AC/CC | 70.0 (0.7) | 61.4 (0.5) | 59.8 (0.6) |
| rs6983267 | p=0.20 | p=0.003 | p=0.59 |
| TT | 71.0 (0.5) | 62.7 (0.3) | 60.3 (0.5) |
| GT | 70.6 (0.3) | 62.1 (0.2) | 59.9 (0.3) |
| GG | 70.0 (0.4) | 61.4 (0.2) | 59.7 (0.4) |
| rs7000448 | p=0.88 | p=0.10 | p=0.81 |
| CC | 70.6 (0.3) | 62.1 (0.2) | 60.1 (0.3) |
| CT | 70.4 (0.3) | 61.8 (0.2) | 59.9 (0.3) |
| TT | 70.7 (0.5) | 62.6 (0.3) | 59.7 (0.6) |
| rs1447295 | p=0.33 | p=0.06 | p=0.21 |
| CC | 70.6 (0.2) | 62.2 (0.2) | 59.8 (0.2) |
| CA/AA | 70.1 (0.4) | 61.5 (0.3) | 60.4 (0.4) |
| rs7008482 | p=0.70 | p=0.22 | |
| TT | 70.7 (0.30 | 61.8 (0.2) | - |
| GT | 70.4 (0.3) | 62.1 (0.2) | - |
| GG | 70.3 (0.6) | 62.4 (0.4) | - |
| rs4430796 | p=0.08 | p=0.02 | p=0.30 |
| GG | 71.0 (0.5) | 62.5 (0.3) | 60.3 (0.5) |
| AG | 70.7 (0.3) | 62.1 (0.2) | 60.1 (0.3) |
| AA | 69.8 (0.4) | 61.5 (0.3) | 59.5 (0.3) |
| rs1859962 | p=0.25 | p=0.03 | p=0.67 |
| TT | 70.6 (0.4) | 62.4 (0.3) | 60.2 (0.4) |
| GT | 70.8 (0.3) | 62.1 (0.2) | 60.0 (0.3) |
| GG | 70.0 (0.4) | 61.5 (0.3) | 59.7 (0.4) |
| # of risk alleles | p=0.008 | p=0.0004 | p=0.40 |
| 0–2 | 72.1 (0.6) | 63.7 (0.4) | 60.2 (0.6) |
| 3 | 71.2 (0.5) | 62.1 (0.3) | 59.8 (0.5) |
| 4 | 70.3 (0.4) | 61.7 (0.3) | 60.7 (0.4) |
| 5 | 70.0 (0.4) | 61.6 (0.3) | 59.5 (0.4) |
| 6–9 | 69.7 (0.5) | 61.8 (0.3) | 59.7 (0.4) |
†
All results from ANOVA