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. Author manuscript; available in PMC: 2011 Mar 26.
Published in final edited form as: Immunity. 2010 Mar 11;32(3):403–413. doi: 10.1016/j.immuni.2010.02.011

Figure 3. Membrane LT, but not LIGHT, is essential for the control of C. rodentium infection.

Figure 3

Ltb−/−, Tnfsf14−/− and WT mice (n=5/group/experiment) were orally inoculated with C. rodentium. Survival rates (A) and body weight change (B) are shown at the indicated time points (n=5). **P< 0.01, ***P< 0.001. C. Histological analysis of representative colons of WT, Ltb−/− and Tnfsf14−/− mice at day 8 after inoculation. H&E staining illustrates transmural inflammation, bacterial abscesses, submucosal leukocyte infiltration and edema in Ltb−/− mice, but not in Tnfsf14−/− mice. Original magnification, ×20. Bars=100 µm. D. Normal bacterial titers in feces of Tnfsf14−/− mice at day 14 after C. rodentium infection. All data are representative of two independent experiments. N.S.- not significant.