TABLE 1.
Baseline characteristics of Olmsted County community residents with bicuspid aortic valve overall and grouped according to the presence or absence of valve degeneration at diagnosis (degeneration score < or ≥3) by echocardiography
| Population | Total | Valve degeneration at diagnosis | ||
|---|---|---|---|---|
| Variable | N=212 | Absent N=184 | Present N=28 | P value |
| Age, years | 32±20 | 28±19 | 52±16 | <0.01 |
| Male sex, n (percent) | 138 (65) | 117 (64) | 21 (75) | 0.23 |
| Hypertension, n (percent) | 43 (20) | 31 (17) | 12 (43) | 0.003 |
| Diabetes, n (percent) | 5 (2) | 3 (2) | 2 (7) | 0.13 |
| Smoking, n (percent) | 56 (26) | 45 (24) | 11 (39) | 0.09 |
| Ejection click, n (percent) | 71 (33) | 67 (36) | 4 (14) | 0.01 |
| Systolic murmur, n (percent) | 162 (76) | 139 (76) | 23 (82) | 0.41 |
| Diastolic murmur, n (percent) | 35 (17) | 30 (17) | 5 (19) | 0.78 |
| Typical BAV, n (percent) | 182 (86) | 157 (85) | 25 (89) | 0.56 |
| Visible raphe, n (percent) | 103 (49) | 83 (45) | 20 (71) | <0.01 |
| Systolic doming, n (percent) | 108 (51) | 96 (52) | 12 (43) | 0.42 |
| Ejection fraction, percent | 63±5 | 64±5 | 63±5 | 0.40 |
| LVD, mm | 48±9 | 48±9 | 50±5 | 0.42 |
| Aortic regurgitation, n (percent) | 100 (47) | 82 (45) | 18 (64) | 0.03 |
| Creatinine, mg/dL | 1.03±0.4 | 1.03±0.4 | 1.06±0.2 | 0.51 |
| Total cholesterol, mg/dL | 198±45 | 193±42 | 220±52 | 0.05 |
BAV=bicuspid aortic valve, LVD=left ventricular end-diastolic dimension.