. Author manuscript; available in PMC: 2010 May 28.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2009 May 12;18(6):1922–1924. doi: 10.1158/1055-9965.EPI-09-0253

Table 1.

Twelve IGF2R missense SNPs used for association testing

SNP	Exon no.	Position^*	Nucleotide change^†	Amino acid change	PolyPhen prediction^‡	Minor allele frequency (%)
						African Americans	Native Hawaiians	Japanese Americans	Latinos	Whites
rs8191746	5	160365688	C>T	Pro203Leu	Probably damaging	2.1	0	0	0	0
rs8191754	6	160368314	C>G	Leu252Val	Benign	12.1	18.4	31.6	6.4	14.5
rs6413491	16	160388299	G>A	Ala724Thr	Benign	3.9	0	0	0.8	0.8
IGF2R_C722T^§	17	160388898	C>T	Pro772Leu	Probably damaging	2.9	0	0	0.70	0
rs8191808	18	160389500	G>C	Val817Leu	Benign	0	0	0.7	0.7	0.7
rs8191844	25	160402919	C>G	Thr1184Ser	Possibly damaging	3.6	0	0	0	0
IGF2R_C1194T^§	25	160402949	C>T	Ser1194Leu	Benign	0	2.2	0	0	0
rs8191859	28	160405480	G>A	Gly1315Glu	Possibly damaging	0	0	8.0	0	0
rs629849	34	160414399	G>A	Gly1619Arg	Benign	2.9	11.0	9.4	6.5	10.7
IGF2R_C1822T^§	37	160419371	C>T	Thr1822Met	—	3.6	0	0	1.43	0
rs8191904	38	160420618	G>A	Arg1832His	Benign	4.8	0	0	0	0.91
rs8191955	48	160446006	C>T	Ala2459Val	Benign	0	2.9	0.7	0	0.7

SNP position based on dbSNP reference assembly (Build 36.3).

^†

Minor allele based on all groups combined.

^‡

^§

Novel missense SNP identified by sequencing.