Table 2.
Associations between IGF2R missense variants and breast cancer risk
| SNP | Genotype | All |
||
|---|---|---|---|---|
| Cases, n (%) | Controls, n (%) | OR (95% CI)* | ||
| rs8191746 | CC | 1584(99.5) | 1862 (99.4) | 1.00 |
| CT | 8 (0.5) | 11 (0.6) | 0.76 (0.30–1.91) | |
| rs8191754 | CC | 1096 (71.1) | 1354 (71.2) | 1.00 |
| CG/GG | 445 (28.9) | 547 (28.8) | 1.14 (0.95–1.30) | |
| rs6413491 | GG | 1568 (98.6) | 1833 (98.4) | 1.00 |
| GA/AA | 23 (1.4) | 29 (1.6) | 0.85 (0.48–1.48) | |
| IGF2R_C722T | CC | 1572 (99.9) | 1923 (100.0) | 1.00 |
| CT | 1 (0.06) | 1 (0.1) | 1.18 (0.07–18.97) | |
| rs8191808 | CC | 1572 (99.1) | 1846 (99.3) | 1.00 |
| CG | 14 (0.9) | 14 (0.8) | 1.28 (0.60–2.73) | |
| rs8191844 | CC | 1562 (98.3) | 1839 (98.6) | 1.00 |
| CG/GG | 27 (1.7) | 26 (1.4) | 1.12 (0.64–1.96) | |
| IGF2R_C1194T | CC | 1574 (97.9) | 1851 (98.7) | 1.00 |
| CT/TT | 34 (2.1) | 25 (1.3) | 1.40 (0.82–2.39) | |
| rs8191859 | GG | 1557 (98.9) | 1877 (97.4) | 1.00 |
| GA/AA | 17 (1.1) | 50 (2.6) | 0.87 (0.48–1.59) | |
| rs629849 | AA | 1283 (82.8) | 1589 (83.7) | 1.00 |
| AG/GG | 267 (17.2) | 309 (16.3) | 1.06 (0.88–1.28) | |
| IGF2R_C1822T | CC | 1572 (98.7) | 1839 (98.7) | 1.00 |
| CT | 21 (1.3) | 24 (1.3) | 0.92 (0.50–1.68) | |
| rs8191904 | GG | 1551 (99.1) | 1893 (98.4) | 1.00 |
| GA/AA | 14 (0.9) | 31 (1.6) | 0.54 (0.28–1.03) | |
| rs8191955 | CC | 1550 (99.5) | 1910 (99.5) | 1.00 |
| CT | 8 (0.5) | 9 (0.5) | 1.50 (0.55–4.14) | |
*
Adjusted for age and racial/ethnic group.