. Author manuscript; available in PMC: 2011 May 1.

Published in final edited form as: J Allergy Clin Immunol. 2010 Apr 15;125(5):1028–1036.e13. doi: 10.1016/j.jaci.2010.02.008

Table II.

Three Comparisons of Inflammatory Protein Microarray Data in Subjects (all treated with corticosteroids) Stratified by Sputum Eosinophils (Eos) and Neutrophils (Neu). Comparison 1 examines differences in mediators between elevated Eos+low Neu and elevated Neu+low Eos; comparison 2 examines differences between elevated Eos+low Neu and elevated Eos+elevated Neu; comparison 3 examines differences between low Neu and elevated Neu without considering Eos. Highlighted proteins were observed to meet criteria in all 3 comparisons.

Protein	1. ≥2%Eos+ <40%Neu (N=6) vs <2%Eos+ ≥40%Neu (N=7)		2. ≥2% Eos+ <40%Neu (N=6) vs ≥2% Eos + ≥40% Neu (N=8)		3. <40% Neu (N=9) vs ≥40% Neu (N=15)
	False positive rate=0–1%		False positive rate=0%		False positive rate=0–1%
	Criteria Failure^*	Increase for ≥40% Neu Fold change	Criteria Failure^*	Increase for ≥40% Neu Fold change	Criteria Failure^*	Increase for ≥40% Neu Fold change
BDNF	^a			3.3		2.2
BLC	^a			3.2	^a
BMP-4		3.3		3.8		2.4
BMP-6		5.5		6.2		3.2
CK b8-1	^a, ^b		^b			2.2
EGF		2.9		3.4		2.0
Eotaxin-2		3.0		5.3		2.1
Eotaxin-3		3.6		3.6		2.7
FGF-7		2.2		2.5	^b
GCP-2		4.0		3.2		2.7
GDNF	^a			2.5	^a, ^b
GM-CSF	^a, ^b			3.8	^b
HGF	^a		ns			3.1
I-309	^a			2.3	^b
IFN-γ		2.6	^a		^a, ^b
IGFBP-1		2.6		2.7		2.1
IGFBP-2		11.7		16.1		7.7
IGF-1		3.1		3.3	^b
IL-1β		9.0		8.4		6.8
IL-2		4.1		2.9		2.1
IL-4		5.9		4.2		2.2
IL-6		3.1		3.5		3.2
IL-10		2.7		3.8		2.1
IL-13		2.8	^a		^a
IL-15		2.1		3.5		2.4
LIGHT		2.1		3.3		2.8
MCP-1	^a			2.7		2.4
MCP-2		3.8		2.5	^a
MDC	^a, ^b			3.0	^b
MIP-1δ		3.9		3.6		2.6
MIP-3α		3.0		4.8		3.0
NT-3		2.4	^a, ^b			2.3
SCF		2.4		2.6		2.1
SDF-1	^a			3.3	^a, ^b
TARC	^a		^a, ^b			2.4
TIMP-2	ns		ns			2.1
TNF-α		4.8		5.5		2.8
TRAIL R3	ns		ns			2.5
uPAR	ns		ns			3.3

ns = not significant (q>5%);

scored <1;

fold increase <2.