Table III.

Sputum Supernatant Mediator Levels Stratified by Sputum %Eos and %Neu. P values meeting Bonferroni correction are in bold font.

	<2%Eos+ <40%Neu	<2%Eos+ ≥40%Neu	≥2%Eos+ <40%Neu	≥2%Eos+ ≥40%Neu	P value For 4 grps*
BDNF pg/ml	9.5 (6–14.5)	18.4 (11.2–29)	15.4 (8–26.5)	20 (14–39)	<0.001
BLC/CXCL13 pg/ml	110±29	223±48	94±20	142±49	0.005
BMP4 pg/ml	4.9±1.5	2.8±0.6	1.8±0.3	3.7±1.1	0.33
EGF pg/ml	159 (108–205)	190 (116–263)	171 (90–212)	199 (145–256)	0.13
Eotaxin 2/CCL24 pg/ml	0.88 (0.01–2.38)	1.13 (0.01–6.78)	2.39 (0.38–4.63)	8.90 (2.5–14.1)	0.022
IFNγ pg/ml	77 (37–149)	47 (2–128)	108 (49–175)	91 (23–125)	0.11
IL-1β pg/ml	104±14	224±56	76±12	228±65	<0.001
IL-8 ng/ml	1.5±0.1	2.1±0.2	1.6±0.2	1.9±0.2	0.017
IL-13 pg/ml	91±18	74±9.9	64±12	81±18	0.55
LIGHT/TNFSF14 pg/ml	36 (12–69)	92 (36–156)	33 (13–108)	58 (24–184)	0.021
MIP-3 α/CCL20 pg/ml	390±41	781±85	341±52	668±121	<0.001
PARC/CCL18 pg/ml	6.7 (0.4–19)	12.7 (4.7–59)	8.3 (1.7–22)	11 (4.6–40)	0.037
TNF α pg/ml	0.3 (0.01–1.24)	1.1 (0.01–2.6)	0.39 (0.01–1.9)	0.7 (0.01–8.1)	0.44

^*ANOVA (mean±SEM) or Kruskal-Wallis (median [25–75% quartiles])