Table IV.
Multiple Linear Regression Analyses for Mediators Significantly Associated with Specific Sputum Cells and Age. The overall R and p values for each mediator are reported with the coefficient and individual p values for specific cell types or age necessary to predict a linear model for the mediator. P values meeting Bonferroni correction are in bold font:
| Cytokine or Growth Factor | R & P value | Br. Epith. Cell Count* | Mac/Mono Count* | Lym Count* | Neu Count* | Eos Count* | Age* |
|---|---|---|---|---|---|---|---|
| BDNF | 0.51 <0.001 |
0.414 0.032 |
0.769 <0.001 |
0.238 0.064 |
|||
| BLC/CXCL13 | 0.388 0.008 |
0.265 0.003 |
−0.131 0.065 |
||||
| BMP4 | 0.393 0.122 |
−0.197 0.0167 |
|||||
| EGF | 0.508 <0.001 |
32.6 0.014 |
26.1 0.02 |
||||
| Eotaxin2 | 0.27 0.29 |
0.28 0.02 |
|||||
| IL-1β | 0.486 <0.001 |
−0.12 0.06 |
0.174 0.016 |
||||
| IL-8 | 0.585 <0.001 |
0.569 0.033 |
0.382 <0.005 |
||||
| IL-13 | 0.171 0.86 |
||||||
| IFNγ | 0.324 0.136 |
19.21 0.08 |
|||||
| LIGHT/TNFSF14 | 0.651 <0.001 |
3.76 0.014 |
2.22 0.007 |
0.097 0.018 |
|||
| MIP3α/CCL20 | 0.621 <0.001 |
5.59 <0.001 |
−2.24 0.014 |
||||
| PARC/CCL18 | 0.553 <0.001 |
0.338 0.006 |
0.184 0.025 |
0.016 0.026 |
|||
| TNF α | 0.567 <0.001 |
0.613 0.062 |
0.458 0.007 |
*
Values under Cell type are regression coefficient and p value for that specific cell. Blank indicates that the cell type or age were not found to be necessary for linear model of association with the cytokine.