Fig. 1.

Mean food intake (±s.e.m.) in five marmots infused with AICAR and four marmots infused with saline in winter. The downward pointing arrow indicates the approximate time that infused AICAR reached the ventricle (~46 h). The upward pointing arrow indicates when the pumps were removed. The cannulae were implanted several weeks before the 7 day ALZET pumps were attached. All marmots had not eaten for at least 2 months prior to infusion. The increase in food intake of the AICAR-infused animals was significantly different from saline-infused animals beginning on day 6 through to day 8 (*P<0.02). The saline-infused animals' food intake was essentially zero.