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Inhibition of intra-tumoral angiogenesis assayed by CD31 staining of microvessels. Vascularization within tumors was detected by an antibody to CD31; representative images were taken under a light microscope (×400) in randomly-selected fields. Tumors of the NS (a) and CDDP (b) treatment groups demonstrated high microvessel density, while those of the Lip-mS (c) and Lip-mS + CDDP (d) treatment groups showed apparent inhibition of angiogenesis.
