Table 1.
Baseline Demographic, Psychiatric and Medical Characteristics of Study Patients (N = 103)
| All Patients N = 103 |
Modafinil Group N = 59 |
Placebo Group N = 44 |
t or X2 |
p | |
|---|---|---|---|---|---|
| Demographic | |||||
| Age, mean (SD) | 46 (9) | 46 (9) | 46 (8) | .165 | .869 |
| Ethnicity, number (%) | |||||
| Black | 41 (40%) | 22 (37%) | 19 (43%) | ||
| White (non-Hispanic) | 35 (34%) | 21 (36%) | 14 (32%) | ||
| .444 | .931 | ||||
| Hispanic | 25 (24%) | 15 (25%) | 10 (23%) | ||
| Other | 2 (2%) | 1 (2%) | 1 (2%) | ||
| Gender, number (%) | |||||
| Men | 88 (85%) | 51 (86%) | 37 (84%) | ||
| .112 | .738 | ||||
| Women | 15 (15%) | 8 (14%) | 7 (16%) | ||
| Years Education, mean (SD) | 14 (3) | 14 (3) | 14 (3) | −.092 | .927 |
| Work Status, number (%) | |||||
| Full time | 14 (14%) | 10 (17%) | 4 (9%) | ||
| Part time | 16 (16%) | 12 (20%) | 4 (9%) | 4.496 | .106 |
| Unemployed | 73 (71%) | 37 (63%) | 36 (82%) | ||
| Psychiatric | |||||
| DSM-IV depression diagnosis1, number, (%) | 41 (40%) | 26 (44%) | 15 (34%) | 1.047 | .306 |
| Taking antidepressant medication, number (%) | 30 (29%) | 15 (25%) | 15 (34%) | .917 | .338 |
| Past drug use history, number, (%) | 52 (51%) | 31 (53%) | 21 (48%) | .234 | .629 |
| 21.1 | - | .079 | |||
| Beck Depression Inventory-II, mean (SD) | 19.6 (9.7) | (10.1) | 17.7 (8.9) | 1.776 | |
| Fatigue Severity Scale, mean (SD) | 51.5 (6.1) | 51.7 (5.9) | 51.2 (6.4) | −.403 | .688 |
| Cognitive Failures Questionnaire | 47 (17) | 48 (18) | 45 (15) | −.633 | .528 |
| Neuropsychological Test Battery Outlier2, | .319 | ||||
| number (%) | 48 (47%) | 25 (42%) | 23 (52%) | .993 | |
| Medical | |||||
| Months since testing HIV+, mean (SD) | 145 (69) | 136 (70) | 157 (65) | 1.540 | .127 |
| AIDS Diagnosis, number, (%) | 6 (64%) | 39 (66%) | 27 (61%) | .246 | .620 |
| Taking antiretroviral therapy, number, (%) | 93 (90%) | 53 (90%) | 40 (91%) | .033 | .855 |
| Hepatitis C, number, (%) | 21 (20%) | 10 (17%) | 11 (25%) | 1.006 | .316 |
| CD4 cell count, mean (SD) | 474 (253) | 486 (250) | 458 (258) | −.560 | .577 |
| 2.51 | 2.35 | .438 | |||
| Log10 Viral Load, mean (SD) | 2.44(1.14) | (1.16) | (1.13) | −.704 | |
1
DSM-IV depression diagnosis of major depressive disorder in partial remission, minor depression, or dysthymia
2
Neuropsychological test battery outlier defined as 1 SD below average on 4+ tests or 2 SD’s on 2+ tests