Table 3.

Cytotoxicity for HT-29 Cells and NF-κB Inhibition of Compounds 1–9^a

compound	cytotoxicityb	NF-κB p50 inhibitionc	NF-κB p65 inhibitionc
1	9.3	2.0	>10
2	3.4	NTd	NTd
3	>10	NTd	NTd
4	>10	>10	>10
5	10.7	>10	>10
6	3.2	>10	>10
7	>10	3.7	2.3
8	3.7	>10	>10
9	8.7	>10	>10

^aAll other compounds isolated in this study were inactive in these assay systems.

^bData are represented as ED₅₀ values (μM), and paclitaxel was used as positive control (ED₅₀, 0.10 nM).

^cData are represented as IC₅₀ values (μM), and rocaglamide was used as positive control (IC₅₀ = 4.0 μM in the NF-κB p50 assay and IC₅₀ = 0.075 μM in the NF-κB p65 assay).

^dNot tested.