Table 4.
Effect of amlodipine and lisinopril on various laboratory parameters in microalbumiuric patients with essential hypertension
| Baseline | 4 weeks | 8 weeks | P value | |
|---|---|---|---|---|
| Serum creatinine (mg/dl) | ||||
| Amlodipine group (n = 60) | 0.88 ± 0.13 | 0.87 ± 0.20 | 0.86 ± 0.15 | 0.4 |
| (0.58-1.02) | (0.56-1.07) | (0.58-1.03) | ||
| Lisinopril group (n = 60) | 0.96 ± 0.22 | 0.91 ± 0.15 | 0.90 ± 0.14 | 0.130 |
| (0.74-1.42) | (0.72-1.06) | (0.66-1.02) | ||
| Serum soeidum (mmol/L) | ||||
| Amlodipine group (n = 60) | 141.23 ± 6.45 | 141.89 ± 5.70 | 139.57 ± 5.29 | 0.13 |
| (128-152) | (129-1500 | (143-148) | ||
| Lisinopril group (n = 60) | 139 ± 5.42 | 140.57 ± 5.09 | 138.45 ± 3.52 | 0.51 |
| (129-144) | (132-150) | (129-140) | ||
| Serum potassium (mmol/L) | ||||
| Amlodipine group (n = 60) | 3.93 ± 0.49 | 3.77 ± 0.52 | 3.88 ± 0.58 | 0.6 |
| (3.2-5.0) | (3.0-4.2) | (3.2-4.3) | ||
| Lisinopril group (n = 60) | 4.11 ± 0.59 | 3.90 ± 0.58 | 4.12 ± 0.67 | 0.9 |
| (3.2-4.81) | (3.0-4.8) | (3.2-4.3) | ||
| Urinary sodium (mmol/L) | ||||
| Amlodipine group (n = 60) | 143.94 ± 11.73 | 143.46 ± 10.39 | 146.52 ± 11.90 | 0.23 |
| (121-156) | (118-145) | (132-162) | ||
| Lisinopril group (n = 60) | 142.85 ± 11.70 | 144.52 ± 6.35 | 144.30 ± 8.40 | 0.4 |
| (125-160) | (135-153) | (129-155) | ||
| Urinary potassium (mmol/L) | ||||
| Amlodipine group (n = 60) | 46.80 ± 14.14 | 47.24 ± 5.74 | 50.24 ± 7.35 | 0.10 |
| (29-56) | (40-56) | (39-60) | ||
| Lisinopril group (n = 60) | 49.24 ± 8.84 | 47.91 ± 8.61 | 52.69 ± 9.62 | 0.06 |
| (38-64) | (38-60) | (30-90) |
Data expressed as mean ± SD; Figures in parentheses indicate range; Amlodepin vs.lisinopril group: P value for all parameters at base line, four and eight weeks > 0.08 (not significant)