Figure 1.

2F8 enhances humoral immunity to ovalbumin (OVA). Antibody dosing and immunization schedule are indicated above the graph. OVA mixed with alum or incomplete Freund’s adjuvant (IFA) is included for comparison. Levels of anti-OVA antibodies were determined by enzyme-linked immunosorbent assay as described in the Materials and methods section. Titre is defined in the Materials and methods section. Results represent at least two independent experiments with three to five mice per group. All treated groups were significantly higher than antibody isotype control-treated mice. Significant comparisons are shown, all others were not significant. ***P < 0·001, **P < 0·01, *P < 0·05.