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. 2010 Jun;130(2):296–306. doi: 10.1111/j.1365-2567.2009.03235.x

Figure 1.

Figure 1

Early cytokine secretion by liver invariant natural killer T (iNKT) cells in collagen-induced arthritis. DBA/1 mice were immunized with collagen II (CII) in complete Freund’s adjuvant (CFA). They were killed 2 hr after an intraperitoneal injection of 4 μg α-galactosylceramide (α-GalCer) on days 6 (n = 10), 22 (n = 10), 42 (n = 10), or 64 (n = 10) post-induction. Liver mononuclear cells were collected and cultured for 16 hr as described in the Material and methods section. Non-immunized (Non-imm) mice (n = 12) were used as controls. Day 6 versus Non-imm: (a) P<0·01; (b) P<0·05; (c) P<0·02. Day 6 versus Day 22: (d) P<0·001; (e) P<0·01. Day 6 versus Day 42: (f) P<0·02; (g) P<0·001. Day 6 versus Day 64: (h) P<0·001. Day 22 versus Day 42: (j) P<0·05; (k) P<0·001. Day 22 versus Day 64: (l) P<0·001. Day 42 versus Day 64: (m) P<0·001 Day 64 versus Non-imm: (n) P<0·05 (Student’s t-test).