Table 1.
Clinical and histological parameters of arthritis in mice treated with anti-CD1d at the early stage of collagen-induced arthritis
| Clinical parameters |
Histological parametersy | ||||
|---|---|---|---|---|---|
| Onset (days) | Incidence | Amax | Inflammation | Destruction | |
| PBS (n = 9) | 45·9 ± 4·2 | 9/9 (100%) | 15·5 ± 3·9 | 1·68 ± 0·36 | 1·67 ± 0·27 |
| Control Ig (n = 7) | 36·3 ± 1·1 | 7/7 (100%) | 12·2 ± 2·3 | 1·43 ± 0·38 | 1·18 ± 0·32 |
| Anti-CD1d (n = 8) | 50·8 ± 3·7** | 5/8 (62%)‡ | 5·3 ± 1·7*† | 0·69 ± 0·35† | 0·50 ± 0·32*† |
The time of arthritis onset is expressed as mean ± SEM. PBS, phosphate-buffered saline; Ig, immunoglobulins; Amax, mean maximum arthritis score.
*
P< 0·05 versus control immunoglobulin.
**
P < 0·01 versus control immunoglobulin.
†
P< 0·05 versus PBS (Mann–Whitney).
‡
P< 0·05 versus PBS (χ2).