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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Antiviral Res. 2010 Feb 16;86(2):188–195. doi: 10.1016/j.antiviral.2010.02.317

Figure 7. Effect of immunosuppresion on survival of HSV-2 infected mice and the levels of replicating virus in neural tissues.

Figure 7

HSV-infected mice were immunosuppressed with 150 mg/kg of cyclophosphamide at 35 and 38 dpi (CY), or remained untreated (No CY). (A) The combined survival of untreated mice and those receiving immunosuppression are shown. (B) Dorsal root ganglia (DRG) and spinal cords (SC) were harvested from sickly mice requiring euthanization and healthy mice at experiment termination (105 dpi). Replicating virus was detected in tissue homogenates by plaque assay, and the percentages of animals with detectable viral replication in each tissue are shown.