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. 2010 Apr 20;285(23):17277–17281. doi: 10.1074/jbc.C110.132944

FIGURE 1.

FIGURE 1.

Acid-evoked off responses in PKD2L1-expressing circumvallate taste cells, but not in fungiform taste cells, in mice. A, phase (left), GFP signal (green, middle), and PKD2L1 immunoreactivity (red, right) images in the same circumvallate taste cell preparation from a GAD67-GFP knock-in mouse. The bar indicates 100 μm. B, a representative trace for change in cytosolic Ca2+ concentration ([Ca2+]i) (340/380 nm ratio) of the cell positive for both GFP and PKD2L1 shown in A. Pseudo-color images at time points a and b indicated in the left trace are also shown. C, traces of [Ca2+]i changes (mean ± S.E., left and right) in response to acid (pH 4.0) and 50 mm KCl by circumvallate (n = 10, left) and fungiform (n = 5, right) taste cells in the presence of extracellular Ca2+ (Ca2+(+)). pap., papillae. D, traces of [Ca2+]i changes (mean ± S.E., left and right) in response to acid (pH 4.0) by circumvallate (n = 8, left) and fungiform (n = 5, right) taste cells in the absence of extracellular Ca2+ (Ca2+(-)).