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Extracellular Cl− facilitates tachyphylaxis of ASIC1a. A, representative sequential currents evoked by pH 5 in either 148 or 0 mm Cl− (MeSO3−) solutions. Cells were bathed in pH 8 solutions for 1 min between pH 5 applications. B, mean current amplitudes of successive pH 5 applications normalized to the first pH 5 current amplitude (n ≥ 6). Lines are fits of single exponentials.
